Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0446CpG motif

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HSV-1 (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It recognize and raise the inflammatory responseNA207138902010Pubchem Assay
PRRID_0446CpG motif

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HSV-1 (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It recognize and raise the inflammatory responseNA207138902010Pubchem Assay
PRRID_0447CpG motif

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HSV-2 (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It recognize and raise the inflammatory responseNA207138902010Pubchem Assay
PRRID_0447CpG motif

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HSV-2 (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It recognize and raise the inflammatory responseNA207138902010Pubchem Assay
PRRID_0448CpG motif

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murine CMV (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainNANANAIt recognize and raise the inflammatory responseNA207138902010NA
PRRID_0448CpG motif

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murine CMV (virus)NANANucleic AcidNaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanDCsLeucine-rich Repeat (LRR) DomainNANANAIt recognize and raise the inflammatory responseNA207138902010NA
PRRID_0449CpG motif

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvementNA207066422010Pubchem Assay
PRRID_0449CpG motif

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvementNA207066422010Pubchem Assay
PRRID_0450CpG motif

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)APP transgenic MicemicrogliaLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032clearance of Aβ from microglial cellsNA207066422010Pubchem Assay
PRRID_0450CpG motif

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)APP transgenic MicemicrogliaLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032clearance of Aβ from microglial cellsNA207066422010Pubchem Assay
PRRID_0451CpG motif

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BacteriaNANANucleic AcidNaturalTheir binding induces Th1 response and promote an increase in IFN-Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It helps in the immunization of the mice to become more efficientNA206360302010Pubchem Assay
PRRID_0451CpG motif

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BacteriaNANANucleic AcidNaturalTheir binding induces Th1 response and promote an increase in IFN-Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It helps in the immunization of the mice to become more efficientNA206360302010Pubchem Assay
PRRID_0452CpG motif

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BacteriaNANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0452CpG motif

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BacteriaNANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0453CpG ODN 1826

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Bacteria5’-tccatgacgttcctgacgtt-3’20Nucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)MacropahgesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA206968242010Pubchem Assay
PRRID_0453CpG ODN 1826

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Bacteria5’-tccatgacgttcctgacgtt-3’20Nucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)MacropahgesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA206968242010Pubchem Assay
PRRID_0454CpG-ODN

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BacteriaNANANucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It delays the onset of prion disease by degrading the prionsNA207066422010Pubchem Assay
PRRID_0454CpG-ODN

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BacteriaNANANucleic AcidSyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It delays the onset of prion disease by degrading the prionsNA207066422010Pubchem Assay
PRRID_0465DNA

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EBV(virus)NANANucleic AcidNaturalIt leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levelsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanMonocytesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It provides antiviral immunityNA207138902010Pubchem Assay
PRRID_0465DNA

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EBV(virus)NANANucleic AcidNaturalIt leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levelsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanMonocytesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It provides antiviral immunityNA207138902010Pubchem Assay
PRRID_0466DNA

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murine CMV (virus)GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC2213Nucleic AcidNaturalIt leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levelsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPDCsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It provides antiviral immunityNA207138902010Pubchem Assay
PRRID_0466DNA

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murine CMV (virus)GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC2213Nucleic AcidNaturalIt leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levelsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPDCsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It provides antiviral immunityNA207138902010Pubchem Assay
PRRID_0467DNA

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Vaccinia(virus)NANANucleic AcidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207092942010Pubchem Assay
PRRID_0467DNA

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Vaccinia(virus)NANANucleic AcidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207092942010Pubchem Assay
PRRID_0468DNA

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Cordyceps sinensis(fungi)TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG685Nucleic AcidNaturalUpon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceBone marrow-derived dendritic cells (BM-DCs).Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It exhibits immunomodulating activity against Cordyceps sinensisLuciferase assay204519012010Pubchem Assay
PRRID_0468DNA

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Cordyceps sinensis(fungi)TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG685Nucleic AcidNaturalUpon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceBone marrow-derived dendritic cells (BM-DCs).Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It exhibits immunomodulating activity against Cordyceps sinensisLuciferase assay204519012010Pubchem Assay
PRRID_0469dsRNA

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VirusNANANucleic AcidNaturalActivates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO15455.fastaO15455904It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0469dsRNA

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VirusNANANucleic AcidNaturalActivates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO15455.fastaO15455904It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0470dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA207395192010Pubchem Assay
PRRID_0470dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA207395192010Pubchem Assay
PRRID_0471dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA207395192010Pubchem Assay
PRRID_0471dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA207395192010Pubchem Assay
PRRID_0472dsRNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_0472dsRNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_0473dsRNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ8R5F7.fastaQ8R5F71025NANA207395192010Pubchem Assay
PRRID_0473dsRNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ8R5F7.fastaQ8R5F71025NANA207395192010Pubchem Assay
PRRID_0474dsRNA

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VirusNANANucleic AcidNaturalThe activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0474dsRNA

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VirusNANANucleic AcidNaturalThe activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0475dsRNA

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VirusNANANucleic AcidNaturalNAPGRP-S3Peptidoglycan Recognition Receptor (PGRPs)Chlamys farrerimantle, gill, kidney and gonadNAQ9VYX7.fastaQ9VYX7203It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0475dsRNA

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VirusNANANucleic AcidNaturalNAPGRP-S3Peptidoglycan Recognition Receptor (PGRPs)Chlamys farrerimantle, gill, kidney and gonadNAQ9VYX7.fastaQ9VYX7203It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0476ds RNA with 5'-triphosphate end

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Sendai (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0476ds RNA with 5'-triphosphate end

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Sendai (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0477ds RNA with 5'-triphosphate end

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Influenza A (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0477ds RNA with 5'-triphosphate end

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Influenza A (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0478dsDNA

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HSV-1 (virus)NANANucleic AcidNaturalit mediate IFNs and cytokine productionZBP-1 or DAIDNA receptorMice (Murine)CytoplasmNAQ9QY24.fastaQ9QY24411It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0478dsDNA

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HSV-1 (virus)NANANucleic AcidNaturalit mediate IFNs and cytokine productionZBP-1 or DAIDNA receptorMice (Murine)CytoplasmNAQ9QY24.fastaQ9QY24411It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0479dsDNA

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HSV-1 (virus)NANANucleic AcidNaturalIt mediate IFNs and cytokine productionRNA Pol-IIIDNA receptorMice (Murine)CytoplasmNAQ9D483.fastaQ9D483533It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0479dsDNA

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HSV-1 (virus)NANANucleic AcidNaturalIt mediate IFNs and cytokine productionRNA Pol-IIIDNA receptorMice (Murine)CytoplasmNAQ9D483.fastaQ9D483533It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0480dsDNA

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VirusNANANucleic AcidNaturalIt activates caspase-1 and release proinflammatory cytokinesAIM2Pattern recognition receptor (PRR)Mice (Murine)CytoplasmNAQ91VJ1.fastaQ91VJ1354It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0480dsDNA

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VirusNANANucleic AcidNaturalIt activates caspase-1 and release proinflammatory cytokinesAIM2Pattern recognition receptor (PRR)Mice (Murine)CytoplasmNAQ91VJ1.fastaQ91VJ1354It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0481dsDNA

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Ectromelia(virus)NANANucleic AcidNaturalIt is necessary for IL-6 productionToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leads to the inflammation of the cellNA207092942010Pubchem Assay
PRRID_0481dsDNA

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Ectromelia(virus)NANANucleic AcidNaturalIt is necessary for IL-6 productionToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leads to the inflammation of the cellNA207092942010Pubchem Assay
PRRID_0482dsDNA

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Rabies virus (virus)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA207066422010Pubchem Assay
PRRID_0482dsDNA

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Rabies virus (virus)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA207066422010Pubchem Assay
PRRID_0483dsDNA

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herpes simplex virus (virus)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA207066422010Pubchem Assay
PRRID_0483dsDNA

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herpes simplex virus (virus)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA207066422010Pubchem Assay
PRRID_0484dsDNA

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vaccinia virus and murine cytomegalovirus (virus)NANANucleic AcidNaturalIt induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1BToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839It is involved in caspase-1-mediated maturation of IL-1βNA206201292010Pubchem Assay
PRRID_0484dsDNA

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vaccinia virus and murine cytomegalovirus (virus)NANANucleic AcidNaturalIt induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1BToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839It is involved in caspase-1-mediated maturation of IL-1βNA206201292010Pubchem Assay
PRRID_0485dsDNA

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Listeria monocytogenes (Bacteria)NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP1Cytosolic receptorRAW264.7 cellscytoplasmNAQ3UZ39.fastaQ3UZ39729It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010Pubchem Assay
PRRID_0485dsDNA

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Listeria monocytogenes (Bacteria)NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP1Cytosolic receptorRAW264.7 cellscytoplasmNAQ3UZ39.fastaQ3UZ39729It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010Pubchem Assay
PRRID_0486dsDNA

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Vesicular stomatitis (virus) NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP2Cytosolic receptorRAW264.7 cellscytoplasmNAQ91WK0.fastaQ91WK0415It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010Pubchem Assay
PRRID_0486dsDNA

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Vesicular stomatitis (virus) NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP2Cytosolic receptorRAW264.7 cellscytoplasmNAQ91WK0.fastaQ91WK0415It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010Pubchem Assay
PRRID_0487dsDNA

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Vaccinia(virus)NANANucleic AcidNaturalIt induces the activation of NF-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)HEK293 cells, PDCsLRRP58682.fastaP586821032TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection.ELISA203085562010Pubchem Assay
PRRID_0487dsDNA

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Vaccinia(virus)NANANucleic AcidNaturalIt induces the activation of NF-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)HEK293 cells, PDCsLRRP58682.fastaP586821032TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection.ELISA203085562010Pubchem Assay
PRRID_0488dsDNA viruses

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HSV, MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0488dsDNA viruses

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HSV, MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0489dsRNA virus

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RSV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0489dsRNA virus

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RSV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0490EBV DNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NR96.fastaQ9NR961032This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0490EBV DNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NR96.fastaQ9NR961032This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0491EBV RNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NYK1.fastaQ9NYK11049This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0491EBV RNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NYK1.fastaQ9NYK11049This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0495endotoxin-free poly(I:C)

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)C57BL/6 Mice (experimental model of lung allergic exacerbation)Airway Epithilium and Dedritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905It significantly increased the airway hyperresponsiveness, the lung inflammationELISA205051412010Pubchem Assay
PRRID_0495endotoxin-free poly(I:C)

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)C57BL/6 Mice (experimental model of lung allergic exacerbation)Airway Epithilium and Dedritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905It significantly increased the airway hyperresponsiveness, the lung inflammationELISA205051412010Pubchem Assay
PRRID_0528Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)SpleenocytesLeucine-rich Repeat (LRR) DomainP58681.fastaP586811050It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasisNA205438572010Pubchem Assay
PRRID_0528Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)SpleenocytesLeucine-rich Repeat (LRR) DomainP58681.fastaP586811050It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasisNA205438572010Pubchem Assay
PRRID_0529Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)SpleenocytesLeucine-rich Repeat (LRR) DomainP58682.fastaP586821032It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasisNA205438572010Pubchem Assay
PRRID_0529Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Mice (Murine)SpleenocytesLeucine-rich Repeat (LRR) DomainP58682.fastaP586821032It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasisNA205438572010Pubchem Assay
PRRID_0530Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0530Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0531Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceHEK293Leucine-rich Repeat (LRR) DomainP58681.fastaP586811050It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0531Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceHEK293Leucine-rich Repeat (LRR) DomainP58681.fastaP586811050It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0533genomic DNA

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HSV-1 and HSV-2 (virus)NANANucleic AcidNaturalIt mediates tumor necrosis factor alpha and CCL5 production in murine macrophagesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)plasmacytoid dendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0533genomic DNA

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HSV-1 and HSV-2 (virus)NANANucleic AcidNaturalIt mediates tumor necrosis factor alpha and CCL5 production in murine macrophagesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)plasmacytoid dendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It has the role in the inflammation.NA207395192010Pubchem Assay
PRRID_0534genomic DNA

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Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0534genomic DNA

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Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0571hypomethylated DNA

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VirusNANANucleic AcidNaturalrelease of proinflammatory cytokines and Pathgen ClearanceToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It has the role in the inflammation.NA207393622010Pubchem Assay
PRRID_0571hypomethylated DNA

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VirusNANANucleic AcidNaturalrelease of proinflammatory cytokines and Pathgen ClearanceToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It has the role in the inflammation.NA207393622010Pubchem Assay
PRRID_0574Imiquimod

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imidazoquinoline (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces inflammatory responses when applied to the skinToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050It leads to the inflammation of the cellNA207399472010Pubchem Assay
PRRID_0574Imiquimod

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imidazoquinoline (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces inflammatory responses when applied to the skinToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050It leads to the inflammation of the cellNA207399472010Pubchem Assay
PRRID_0575Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces translocation of NF-kB and production of IFN-α, TNF-α, IL-6, and IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Cyprinus carpio Lhead kidneyLeucine-rich Repeat (LRR) DomainNANANAIt has the role in the inflammation.NA207096112010NA
PRRID_0575Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces translocation of NF-kB and production of IFN-α, TNF-α, IL-6, and IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Cyprinus carpio Lhead kidneyLeucine-rich Repeat (LRR) DomainNANANAIt has the role in the inflammation.NA207096112010NA
PRRID_0576Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERNToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANASuppresses angiogenesis and presents proapoptotic activityNA206360302010NA
PRRID_0576Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERNToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANASuppresses angiogenesis and presents proapoptotic activityNA206360302010NA
PRRID_0578imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0578imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0579imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0579imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0580IMO-1

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NA5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0580IMO-1

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NA5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay